Progesterone and Treating Glioblastoma Multiforme

IMG_6904

Charles S. Cobbs, MD

The Gregory Foltz, MD Endowed Director
Ben & Catherine Ivy Center for
Advanced Brain Tumor Treatment
Swedish Neuroscience Specialists

 

Recently a paper was published in the Journal of Steroid Biochemistry and Molecular Biology entitled “Anti-tumor effects of progesterone in human glioblastoma multiforme: Role of PI3K/Akt/mTOR signaling”.  http://news.emory.edu/stories/2014/06/labland_progesterone_for_brain_cancer/campus.html 

This paper has received some attention amongst the brain tumor community as a possible indicator that progesterone may be a new drug to be used for brain tumor treatment. In the study they treated several glioblastoma cell lines with progesterone and they treated some mice bearing human glioblastoma tumors. They did find that some of the tumor growth was inhibited in both the cells and culture and in mice.  Results of this study were thought to suggest the possibility that progesterone might be a novel glioblastoma treatment. However, I would caution that this study is extraordinarily preliminary in terms of using progesterone for human brain tumors. We have little understanding whether or not this would be a drug that can be utilized in glioblastoma patients.

 For patients with glioblastoma, I do not think they should look to this study as representing something that might be a new treatment modality within the next several years.

 

 

 

 

 

Disclaimer: This is a personal blog. Any views or opinions represented in this blog are personal and belong solely to the blog author and do not represent those of people, institutions or organizations that the owner may or may not be associated with in professional or personal capacity, unless explicitly stated.  All content provided on this blog is for informational purposes only. The owner of this blog makes no representations as to the accuracy or completeness of any information on this site or found by following any link on this site. The owner will not be liable for any errors or omissions in this information nor for the availability of this information. The owner will not be liable for any losses, injuries, or damages from the display or use of this information. These terms and conditions of use are subject to change at anytime and without notice.

All content provided on this blog is for informational purposes only. The owner of this blog makes no representations as to the accuracy or completeness of any information on this site or found by following any link on this site. The owner will not be liable for any errors or omissions in this information nor for the availability of this information. The owner will not be liable for any losses, injuries, or damages from the display or use of this information.

Leave a Reply